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Immunology of Taenia solium taeniasis and human cysticercosis
Author(s) -
Garcia H. H.,
Rodriguez S.,
Friedland J. S.
Publication year - 2014
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/pim.12126
Subject(s) - cysticercosis , taenia solium , taeniasis , neurocysticercosis , biology , immunology , neglected tropical diseases , helminthiasis , taenia , disease , helminths , medicine , cestode infections , pathology , zoology
Summary The life cycle of T aenia solium , the pork tapeworm, is continuously closed in many rural settings in developing countries when free roaming pigs ingest human stools containing T . solium eggs and develop cysticercosis, and humans ingest pork infected with cystic larvae and develop intestinal taeniasis, or may also accidentally acquire cysticercosis by faecal‐oral contamination. Cysticercosis of the human nervous system, neurocysticercosis, is a major cause of seizures and other neurological morbidity in most of the world. The dynamics of exposure, infection and disease as well as the location of parasites result in a complex interaction which involves immune evasion mechanisms and involutive or progressive disease along time. Moreover, existing data are limited by the relative lack of animal models. This manuscript revises the available information on the immunology of human taeniasis and cysticercosis.