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Imaging host– L eishmani a interactions: significance in visceral leishmaniasis
Author(s) -
Forestier C.L.
Publication year - 2013
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/pim.12044
Subject(s) - visceral leishmaniasis , biology , disease , leishmaniasis , immunology , immune system , host (biology) , leishmania , parasitic disease , identification (biology) , pathology , parasite hosting , medicine , ecology , world wide web , computer science
Summary Leishmaniasis is a neglected disease that is associated with a spectrum of clinical manifestations ranging from self‐healing cutaneous lesions to fatal visceral infections, which primarily depends on the parasite species. In visceral leishmaniasis ( VL ), as opposed to cutaneous leishmaniasis ( CL ), parasites that infect host cells at the sand fly bite site have the striking ability to disseminate to visceral organs where they proliferate and persist for long periods of time. Imaging the dynamics of the host– L eishmania interaction in VL provides a powerful approach to understanding the mechanisms underlying host cell invasion, L eishmania dissemination and persistence within visceral organs and, to dissecting the immune responses to infection. Therefore, by allowing the visualization of the critical steps involved in the pathogenesis of VL , state‐of‐the‐art microscopy technologies have the great potential to aid in the identification of better intervention strategies for this devastating disease. In this review, we emphasize the current knowledge and the potential significance of imaging technologies in understanding the infection process of visceralizing L eishmania species. Then, we discuss how application of innovative microscopy technologies to the study of VL will provide rich opportunities for investigating host–parasite interactions at a previously unexplored level and elucidating visceral disease‐promoting mechanisms.

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