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Pellagra a review exploring causes and mechanisms, including isoniazid‐induced pellagra
Author(s) -
Prabhu Dhanashree,
Dawe Robert S.,
Mponda Kelvin
Publication year - 2021
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/phpp.12659
Subject(s) - pellagra , isoniazid , niacin , dementia , medicine , leprosy , dermatology , tuberculosis , disease , pathology
Pellagra is a clinical syndrome caused by a deficiency of niacin (nicotinic acid) and/or its precursor tryptophan. The cardinal manifestations are 4 D’s: dermatitis, diarrhoea, dementia and in worst case death. Increased use of isoniazid prophylaxis along with antiretroviral therapy in countries where latent tuberculosis is common has been associated with increased presentations with pellagra.