Premium
Comparison of efficacy and safety profile for home NB‐UVB vs. outpatient NB‐UVB in the treatment of non‐segmental vitiligo: A prospective cohort study
Author(s) -
Zhang Li,
Wang Xiuxiu,
Chen Shujun,
Zhao Juemin,
Wu Jiaqiang,
Jiang Min,
Zhang Chengfeng,
Xiang Leihong
Publication year - 2019
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/phpp.12462
Subject(s) - vitiligo , medicine , adverse effect , dermatology , outpatient clinic , quality of life (healthcare) , ultraviolet b , prospective cohort study , nursing
Summary Objective The aim of this study was to evaluate the efficacy and safety of home and outpatient narrowband ultraviolet B light (NB‐UVB) for the treatment of non‐segmental vitiligo. Methods A total of 94 patients with non‐segmental vitiligo were enrolled. Forty‐eight patients were treated with home NB‐UVB, and the other 46 patients were treated with outpatient NB‐UVB over a period of 6 months. The efficacy, patient quality of life, and adverse events were assessed at month 3 and month 6 after treatment. Results There was no significant difference in repigmentation and VASI‐reverse (VR) rates between outpatient NB‐UVB and home NB‐UVB groups. VR was higher in outpatient NB‐UVB group at month 3, and similar at month 6. For long‐standing vitiligo, VR was higher in the outpatient NB‐UVB group compared with home NB‐UVB group after 6 months of treatment. In recent vitiligo, the VR was similar between the two groups. Additionally, vitiligo‐specific health‐related quality‐of‐life instrument (VitiQoL) score was similar, and the adverse effects were minimal among the two groups. Conclusions The efficacy and safety of home NB‐UVB and outpatient NB‐UVB phototherapy for non‐segmental vitiligo were comparable. According to our results, those with long‐standing vitiligo may be recommended to receive outpatient NB‐UVB phototherapy.