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Unique profile of antimicrobial peptide expression in polymorphic light eruption lesions compared to healthy skin, atopic dermatitis, and psoriasis
Author(s) -
Patra VijayKumar,
Mayer Gerlinde,
GruberWackernagel Alexandra,
Horn Michael,
Lembo Serena,
Wolf Peter
Publication year - 2018
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/phpp.12355
Subject(s) - antimicrobial peptides , psoriasis , atopic dermatitis , dermis , immunology , epidermis (zoology) , medicine , innate immune system , dermatology , stratum granulosum , immune system , pathology , biology , antimicrobial , microbiology and biotechnology , stratum corneum , anatomy
Summary Background Polymorphic light eruption ( PLE ) has been attributed to type IV , most likely delayed‐type hypersensitivity response (adaptive immunity) but little is known on innate immunity, especially antimicrobial peptides ( AMP s) in the disease. Abnormalities in AMP expression have been linked to pathological skin conditions such as atopic dermatitis ( AD ) and psoriasis. Methods Antimicrobial peptide profiling was carried out in PLE skin samples (n,12) compared with that of healthy (n,13), atopic (n,6), and psoriatic skin (n,6). Results Compared to healthy skin, we observed increased expression of psoriasin and RNA se7 (both mostly in stratum granulosum of the epidermis), HBD ‐2 (in the cellular infiltrate of the dermis), and LL 37 (mostly in and around blood vessels and glands) in PLE lesional skin, a similar expression profile as present in psoriatic skin and different to that of AD (with little or no expression of psoriasin, RNA se7, HBD ‐2, and LL 37). HBD ‐3 was downregulated in PLE compared to its high expression in the epidermis and dermis of healthy skin, AD , and psoriasis. Conclusion The unique profile of differentially expressed AMP s in PLE implies a role in the pathophysiology of the disease, possibly directly or indirectly linked to the microbiome of the skin.