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Nonablative fractional laser‐assisted daylight photodynamic therapy with topical methyl aminolevulinate for moderate to severe facial acne vulgaris: Results of a randomized and comparative study
Author(s) -
Kim Tae In,
Ahn HyeJin,
Kang In Hye,
Jeong KiHeon,
Kim Nack In,
Shin Min Kyung
Publication year - 2017
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/phpp.12312
Subject(s) - acne , photodynamic therapy , medicine , lesion , dermatology , randomized controlled trial , surgery , chemistry , organic chemistry
Summary Background Photodynamic therapy ( PDT ) has been reported as an effective alternative treatment for patients with acne. Purpose To evaluate the efficacy and safety of DL ‐ PDT in moderate to severe acne and to compare outcomes with those of laser‐assisted daylight photodynamic therapy. Methods Patients were randomly assigned to either a DL ‐ PDT group (D group) or a fractional laser‐assisted DL ‐ PDT group (F group). The outcomes were assessed by measuring acne lesion counts and severity grade at 4, 8, 12, and 16 weeks after therapy commenced. Results Twenty‐eight subjects completed the study. Compared with baseline, the mean inflammatory lesion counts significantly decreased by 36.0% in the D group and 51.8% in the F group at 8 weeks ( P <.001). The mean acne severity grades in both groups significantly decreased starting at 4 weeks ( P =.012), and the beneficial effects lasted 16 weeks. Conclusion DL ‐ PDT with MAL shows clinically good responses to inflammatory lesions and is well tolerated in patients with moderate to severe acne.