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Photo‐induced graft‐versus‐host disease
Author(s) -
Hardy Juliette M.,
Marguery MarieClaude,
Huynh Anne,
Borel Cécile,
Apoil Pol André,
Lamant Laurence,
Tournier Emilie,
Alberto Chloé,
Pauwels Céline,
Thomas Marianne,
Mazereeuw Hautier Juliette,
Paul Carle,
Bulai Livideanu Cristina
Publication year - 2016
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/phpp.12273
Subject(s) - graft versus host disease , medicine , immunology , disease , haematopoiesis , transplantation , chronic disease , stem cell , pathology , biology , genetics
Summary Overlap chronic graft‐versus‐host disease (GVHD) associates both features of acute and chronic GVHD. Trigger factors for chronic GVHD are unclear. We describe two patients who received allogenic haematopoietic stem‐cell transplantation, and who later developed overlap chronic GVHD after sun exposure. Available data from in vivo investigations suggest ultraviolet B radiation (UVB) has a beneficial effect on acute and chronic GVHD. The role of sun irradiation as a trigger for isomorphic cutaneous GVHD has been rarely reported in the literature. Herein, we demonstrate for the first time, using repetitive broadband phototesting, that UVB triggers chronic GVHD.