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The gender differences in the inhibitory action of UVB ‐induced melanocyte activation by the administration of tranexamic acid
Author(s) -
Hiramoto Keiichi,
Yamate Yurika,
Sugiyama Daijiro,
Takahashi Yumi,
Mafune Eiichi
Publication year - 2016
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/phpp.12231
Subject(s) - tranexamic acid , endocrinology , antagonist , receptor , medicine , melanocyte stimulating hormone , melanocyte , pharmacology , chemistry , melanoma , cancer research , surgery , blood loss
Summary Background Tranexamic acid has an inhibitory action on ultraviolet ( UV ) B‐induced melanocyte activation. This study examined the sex differences in the inhibitory action of tranexamic acid on UVB ‐induced melanocyte activation. Methods We irradiated the eye and ear of male and female mice with UVB at a dose of 1.0 kJ/m 2 using a 20SE sunlamp. We orally administered tranexamic acid (750 mg/kg/day) at 30 min before UVB exposure. Results Tranexamic acid inhibited the UVB ‐induced epidermal melanocyte activation, and the effect was more remarkable under UVB eye irradiation than under UVB ear irradiation. Furthermore, the melanocyte activity suppression effect was stronger in female mice than in male mice. Following the administration of tranexamic acid, the female displayed increased blood levels of β‐endorphin and μ‐opioid receptor and estradiol receptor β expression in comparison with the male. Furthermore, the effect of melanocyte activity suppression in the female mice was decreased by the administration of tamoxifen (antagonist of estrogen receptor) or naltrexone (antagonist of μ‐opioid receptor). Conclusions These results suggest that the suppression by tranexamic acid of the UVB ‐induced melanocyte activation ( UVB sensitivity) is stronger in female mice than in male mice and that female hormones and β‐endorphin play an important role in this sex difference.