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Treatment of localized mycosis fungoides with digital UV photochemotherapy
Author(s) -
Reidel Ulrich,
Bechstein Sarah,
LangeAsschenfeldt Bernhard,
Beyer Marc,
Vandersee Staffan
Publication year - 2015
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/phpp.12196
Subject(s) - mycosis fungoides , dermatology , peripheral t cell lymphoma , medicine , immunology , lymphoma , t cell , immune system
Abstract Background/Purpose Photochemochemotherapy with 8‐methoxypsoralen and UV ‐A light ( PUVA ) is a well‐established treatment for mycosis fungoides ( MF ), although evidence for this therapy by means of prospective studies is scarce. However, long‐term risks of PUVA are premature skin aging and development of nonmelanoma skin cancer. We therefore evaluated a device for targeted UV therapy, which reduces irradiation of unaffected skin in MF patients. Methods Ten patients with patch‐ or plaque‐type MF affecting less than 10% body surface area were included in a prospective study. A total of 14 lesions were treated with cream PUVA using the digital phototherapy device skintrek ® PT 3. Results Seven of ten patients showed response to treatment. Complete clinical remission was achieved in four of ten patients (complete remission of seven of fourteen treated lesions) after an average of 13.4 weeks and an average cumulative UV dose of 42.6 J/cm 2 in a mean of 31.2 treatment sessions. Adverse events were rare and of mild severity. Conclusions This study is the first prospective trial demonstrating efficacy and safety of cream PUVA in MF patients. As healthy adjacent skin remains unaffected, the potential to reduce the carcinogenic risk of PUVA treatment makes this new method a promising therapeutic option for localized MF .