Effect of narrow band‐ultraviolet  B  on  CD 4 +   CD 25 high   F ox P 3 +  T ‐lymphocytes in the peripheral blood of vitiligo patients | Zendy

Moftah Nayera H. | Zendy; ElBarbary Rasha A. H. | Zendy; Ismail Mona A. | Zendy; Ali Nancy A. M. | Zendy

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Effect of narrow band‐ultraviolet B on CD 4 + CD 25 high F ox P 3 + T ‐lymphocytes in the peripheral blood of vitiligo patients

Author(s) -

Moftah Nayera H.,

ElBarbary Rasha A. H.,

Ismail Mona A.,

Ali Nancy A. M.

Publication year - 2014

Publication title -

photodermatology, photoimmunology and photomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.736

H-Index - 60

eISSN - 1600-0781

pISSN - 0905-4383

DOI - 10.1111/phpp.12104

Subject(s) - vitiligo , medicine , il 2 receptor , ultraviolet b , foxp3 , immunology , peripheral blood , dermatology , t cell , immune system

Summary Background It is widely believed that an imbalance between activated CD 8 + T cells and regulatory T cells ( T regs) exists in patients with vitiligo. Although there is evidence that narrow band ultraviolet ( NB ‐ UVB ) irradiation can induce T regs' number and activity, but up to our knowledge, none of the published studies involved the possible effect of NB ‐ UVB on T regs in vitiligo. Objective To evaluate the effect of NB ‐ UVB on circulating CD 4 + CD 25 high F ox P 3 + regulatory T cells ( F ox P 3 + T regs) in vitiligo. Methods This prospective analytic study included 20 patients with active non‐segmental vitiligo and 20 healthy controls. The patients were exposed to NB ‐ UVB therapy three times per week for 30 sessions. Blood sampling before and after NB ‐ UVB phototherapy was done to evaluate circulating CD 4 + CD 25 high T regs and F oxp3 + T regs. Results The CD 4 + CD 25 high T regs% and F ox P 3 + T regs% were significantly higher in vitiligo patients compared with controls. NB ‐ UVB therapy decreased both of them in patients, but they did not reach those of controls. Each of circulating CD 4 + CD 25 high T regs% and F ox P 3 + T regs% didn't correlate with either extent or activity of vitiligo before or after NB ‐ UVB . Conclusion T regs functional defect is probably having an impact on NSV . NB ‐ UVB may improve the function of T regs. Understanding the mechanisms through which NB ‐ UVB exert its effect on reducing the number of circulating T regs would help open up the paths for future therapeutic options.

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