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Targeted photochemotherapy in alopecia areata
Author(s) -
Açıkgöz Gürol,
Yeşil Hakan,
Çalışkan Ercan,
Tunca Mustafa,
Akar Ahmet
Publication year - 2013
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1111/phpp.12073
Subject(s) - alopecia areata , medicine , vellus hair , dermatology , hair loss , scalp
Summary Background/Purpose Alopecia areata ( AA ) is a common cause of localized non‐scarring alopecia. Usage of targeted UVA after the topical application of 8‐methoxypsoralen (8‐ MOP ) is one of the rising treatment modalities for AA . Our aim was to assess the efficacy and safety of topical 8‐ MOP plus targeted UVA phototherapy in the treatment of patchy AA . Methods Seven patchy AA patients were treated by topical 8‐ MOP application to the lesions followed by UVA irradiation 3 times a week, with 15 to 24 sessions in total. At the end of the treatment all patients were evaluated for response on a four‐point scale (0 = no hair, 1 = white vellus hair, 2 = regrowth cosmetically acceptable for the patient, 3 = complete hair growth). Results The mean cumulative UVA dose was from 7.5 to 39.6 J/cm 2 . For all 7 patients, average response score was calculated as 2, which means cosmetically acceptable regrowth. Conclusion Targeted UVA phototherapy combined with topical 8‐ MOP may be an effective and safe alternative treatment protocol for patchy AA , which should be kept in mind in order to choose the best for the patient, especially for patients incompatible with other treatments that are systemic and invasive.

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