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Role of Hypotaurine in Protection against UVA‐Induced Damage in Keratinocytes
Author(s) -
Baseggio Conrado Alessia,
Fanelli Sergio,
McGuire Victoria Anne,
Ibbotson Sally Helen
Publication year - 2020
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.13334
Subject(s) - hypotaurine , taurine , keratinocyte , pharmacology , cytotoxicity , chemistry , biochemistry , photoaging , biology , in vitro , medicine , dermatology , amino acid
Photoageing and skin cancer are major causes of morbidity and are a high cost to society. Interest in the development of photoprotective agents for inclusion in topical cosmetic and sunscreen products is profound. Recently, amino acids with a sulfinic group, notably hypotaurine, have been included as ingredients in cosmetic preparations. However, the mechanism of action of hypotaurine as a possible anti‐aging agent is unknown, despite its use as a free radical scavenger. To address this issue, we investigated hypotaurine uptake in a human keratinocyte model and examined its effect on UVR‐induced cytotoxicity. Hypotaurine was taken up by keratinocytes in a time‐ and concentration‐dependent manner, with levels remaining significantly above baseline 48 h after washout. A cytoprotective effect of pre‐incubation with 2.5–5 m M hypotaurine was shown as indicated by increased cell viability when keratinocytes were irradiated with UVA at 5 or 10 Jcm ‐2 , with the level of hypotaurine also significantly reduced. These findings indicate a potential cytoprotective effect of hypotaurine against the deleterious effects of UVA irradiation. This provides support for further studies to evaluate the potential photoprotective benefits of hypotaurine supplementation of topical cosmetic and sunscreen products.