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Systematic Review of Photobiomodulation Therapy (PBMT) on the Experimental Calcaneal Tendon Injury in Rats
Author(s) -
Lopes Silva Rauena Souto Diogo,
Pessoa Diego Rodrigues,
Mariano Rafaela Rodrigues,
Castro Ana Beatriz Silva,
Oliveira Rauirys Alencar,
Ferraresi Cleber
Publication year - 2020
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.13262
Subject(s) - medicine , tendon , tendinopathy , achilles tendon , low level laser therapy , laser therapy , tendinitis , surgery , laser , physics , optics
This systematic review analyzed the light parameters and the effects of photobiomodulation therapy (PBMT) through low‐level laser therapy (LLLT) and/or LED (light‐emitting diode) on tendon repair of rats submitted to calcaneal injury. This study was conducted in accordance with the guidelines of the Preferred Reporting Items for Meta‐Analysis, and PubMed and MEDLINE databases were accessed to search eligible studies published in English. The search terms were as follows: "Achilles tendon" or "Calcaneal tendon" or "tendon injuries" or "soft tissue injuries" and "tendinopathy" or "tendinitis" and "low‐level light therapy" or "low‐level laser therapy" or "low intensity power therapy" or "light‐emitting diode" or photobiomodulation." The SYRCLE ( SYstematic Review Center for Laboratory animal Experimentation ) risks of bias was used to assess the risk of bias for selected studies. A total of 225 studies were found based on the descriptors used, and only 33 studies were eligible. Light parameters identified per point of irradiation were approximately 60 mW (continuous mode at infrared spectra), 2 W cm −2 , 2 J and 45 J cm −2 . Light parameters at red spectra, continuous versus pulsed mode, and PBMT combined or compared with other therapies such as ultrasound, and studies using unhealthy rats (ovariectomized and/or diabetic models) were also identified and grouped according to these similarities. The main effects found were decreased inflammatory markers and signs of inflammatory process. PBMT (laser/LED) has positive effects in reducing the inflammatory and time for tissue repair in animal models of tendon injury and/or tendinitis using parameters identified.