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Exploring BODIPY Derivatives as Singlet Oxygen Photosensitizers for PDT
Author(s) -
PrietoMontero Ruth,
PrietoCastañeda Alejandro,
SolaLlano Rebeca,
Agarrabeitia Antonia R.,
GarcíaFresnadillo David,
LópezArbeloa Iñigo,
Villanueva Angeles,
Ortiz María J.,
Moya Santiago,
MartínezMartínez Virginia
Publication year - 2020
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.13232
Subject(s) - bodipy , singlet oxygen , photodynamic therapy , chromophore , chemistry , photochemistry , combinatorial chemistry , oxygen , organic chemistry , fluorescence , physics , quantum mechanics
Abstract This minireview is devoted to honoring the memory of Dr. Thomas Dougherty, a pioneer of modern photodynamic therapy (PDT). It compiles the most important inputs made by our research group since 2012 in the development of new photosensitizers based on BODIPY chromophore which, thanks to the rich BODIPY chemistry, allows a finely tuned design of the photophysical properties of this family of dyes to serve as efficient photosensitizers for the generation of singlet oxygen. These two factors, photophysical tuning and workable chemistry, have turned BODIPY chromophore as one of the most promising dyes for the development of improved photosensitizers for PDT. In this line, this minireview is mainly related to the establishment of chemical methods and structural designs for enabling efficient singlet oxygen generation in BODIPYs. The approaches include the incorporation of heavy atoms, such as halogens (iodine or bromine) in different number and positions on the BODIPY scaffold, and also transition metal atoms, by their complexation with Ir(III) center, for instance. On the other hand, low‐toxicity approaches, without involving heavy metals, have been developed by preparing several orthogonal BODIPY dimers with different substitution patterns. The advantages and drawbacks of all these diverse molecular designs based on BODIPY structural framework are described.