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Analyzing the Synergistic Effects of Antioxidants in Combating Photoaging Using Model Nematode, Caenorhabditis elegans
Author(s) -
Prasanth Mani Iyer,
Gayathri Subramanyam,
Bhaskar James Prabhanand,
Krishnan Venkateswaran,
Balamurugan Krishnaswamy
Publication year - 2019
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.13167
Subject(s) - photoaging , caenorhabditis elegans , antioxidant , naringenin , chemistry , biochemistry , biology , gene , genetics , flavonoid
Aging, a universal and unique process, occurs both intrinsically (chronological) and extrinsically (photoaging). Ultraviolet‐A (UV‐A)‐mediated stress is a growing health hazard to mankind as it is the major cause of photoaging, which could lead to much damage of skin cells and tissues ranging from tan, burn, or even cancer. The present study focuses on the role of antioxidants and other natural compounds which have been widely used in oral/topical applications to combat and delay the effects of photoaging using model nematode Caenorhabditis elegans . Compounds like green tea extract, naringenin, and naringin, which are known for their antioxidant properties, were able to extend life span and healthspan of the nematode in normal as well as under UV‐A‐mediated stress conditions. Regulation of both the stress‐responsive genes ( skn‐1 and sir‐2.1 ) and the aging‐regulating genes ( daf‐2 and age‐1 ) was attributable for these conditions. Interestingly, it was observed that these compounds when combined in equal ratios by weight worked synergistically to combat the aging process. Pronounced synergistic effects were observed during UV‐A‐mediated stress conditions, suggesting that these could be used as potential antiphotoaging compounds which will be of greater significance for health‐based research.

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