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How Fast Can Thiols Bind to the Gold Nanoparticle Surface?
Author(s) -
Bard Amanda,
Rondon Rebeca,
Marquez Daniela T.,
Lanterna Anabel E.,
Scaiano Juan C.
Publication year - 2018
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.13010
Subject(s) - kinetics , thiol , chemistry , colloidal gold , fluorescence , surface modification , fluorescence spectroscopy , nanoparticle , photochemistry , combinatorial chemistry , nanotechnology , organic chemistry , materials science , physics , quantum mechanics
Kinetics of gold nanoparticle surface modification with thiols can take more than one hour for completion. 7‐mercapto‐4‐methylcoumarin can be used to follow the process by fluorescence spectroscopy and serves as a convenient molecular probe to determine relative kinetics. SERS studies with aromatic thiols further support the slow surface modification kinetics observed by fluorescence spectroscopy. The formation of thiolate bonds is a relatively slow process; we recommend one to two hour wait for thiol binding to be essentially complete, while for disulfides, overnight incubation is suggested.