Premium
Molecular Photoacoustic Contrast Agents: Design Principles & Applications
Author(s) -
Borg Raymond E.,
Rochford Jonathan
Publication year - 2018
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.12967
Subject(s) - photoacoustic imaging in biomedicine , nanotechnology , contrast (vision) , molecular imaging , resolution (logic) , high contrast , image resolution , chemistry , materials science , computer science , in vivo , optics , physics , biology , artificial intelligence , microbiology and biotechnology
Photoacoustic imaging ( PAI ) is a rapidly growing field which offers high spatial resolution and high contrast for deep‐tissue imaging in vivo . PAI is nonionizing and noninvasive and combines the optical resolution of fluorescence imaging with the spatial resolution of ultrasound imaging. In particular, the development of exogenous PA contrast agents has gained significant momentum of late with a vastly expanding complexity of dye materials under investigation ranging from small molecules to macromolecular proteins, polymeric and inorganic nanoparticles. The goal of this review is to survey the current state of the art in molecular photoacoustic contrast agents ( MPAC s) for applications in biomedical imaging. The fundamental design principles of MPAC s are presented and a review of prior reports spanning from early‐to‐current literature is put forth.