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Is Antimicrobial Photodynamic Therapy Effective for Microbial Load Reduction in Peri‐implantitis Treatment? A Systematic Review and Meta‐Analysis
Author(s) -
Fraga Renato Silva,
Antunes Lívia Azeredo Alves,
Fontes Karla Bianca Fernandes da Costa,
Küchler Erika Calvano,
Iorio Natalia Lopes Pontes Póvoa,
Antunes Leonardo Santos
Publication year - 2018
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.12901
Subject(s) - peri implantitis , prevotella intermedia , confidence interval , cochrane library , medicine , aggregatibacter actinomycetemcomitans , meta analysis , antimicrobial , porphyromonas gingivalis , chronic periodontitis , periodontitis , dentistry , surgery , microbiology and biotechnology , biology , implant
The systematic review and meta‐analysis were undertaken to evaluate the effectiveness of antimicrobial photodynamic therapy ( aPDT ) in the microbiological alteration beneficial to peri‐implantitis treatment. This study is registered with PROSPERO , number CRD 42017064215. Bibliographic databases including Cochrane Library, Web of Science, Scopus and PubMed were searched from inception to 8 January 2017. The search strategy was assembled from the following MeSH Terms: “Photochemotherapy,” “Dental Implants” and “Peri‐Implantitis.” Unspecific free‐text words and related terms were also included. The Cochrane Collaboration's tool was used to evaluate the risk of bias of included studies. The random‐effect model was chosen, and heterogeneity was evaluated using the I 2 test. Three studies met the inclusion criteria. Meta‐analysis demonstrated an association between aPDT and reduction in viable bacteria counts for: Aggregatibacter actinomycetemcomitans ( OR = 1.31; confidence interval = 1.13, 1.49; P < 0.00001), Porphyromonas gingivalis ( OR = 4.08; confidence interval = 3.22, 4.94; P < 0.00001) and Prevotella intermedia ( OR = 1.66; confidence interval = 1.06, 2.26; P < 0.00001). A aPDT appears to be effective in bacterial load reduction in peri‐implantitis and has a positive potential as an alternative therapy for peri‐implantitis.