Premium
Extracellular Matrix Containing in vitro Three‐dimensional Tumor Models in Photodynamic Therapy‐related Research
Author(s) -
Čunderlíková Beata
Publication year - 2018
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.12859
Subject(s) - photodynamic therapy , extracellular matrix , in vitro , tumor cells , extracellular , 3d cell culture , matrix (chemical analysis) , cancer therapy , microbiology and biotechnology , computational biology , chemistry , cancer research , cancer , biology , biophysics , computer science , biochemistry , genetics , organic chemistry , chromatography
Three‐dimensional (3D) tumor models have been intensively evaluated for their use in cancer research, and there is a strong rationale behind using 3D cell cultures in photodynamic therapy (PDT)‐related experimentation. In this contribution, it is explained why 3D cell cultures containing extracellular matrix (ECM) are preferred for this purpose. Results of experimental studies utilizing ECM‐containing 3D cellular models in PDT research are summarized. Finally, the design of in vitro 3D models that would provide clinically relevant information is discussed.