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A Photosensitizer Lanthanide Nanoparticle Formulation that Induces Singlet Oxygen with Direct Light Excitation, But Not By Photon or X‐ray Energy Transfer
Author(s) -
Chouikrat Rima,
Baros Francis,
André JeanClaude,
Vanderesse Régis,
Viana Bruno,
Bulin AnneLaure,
Dujardin Christophe,
Arnoux Philippe,
Verelst Marc,
Frochot Céline
Publication year - 2017
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.12799
Subject(s) - photosensitizer , singlet oxygen , photochemistry , photodynamic therapy , lanthanide , nanoparticle , conjugated system , chemistry , chlorin , zinc , covalent bond , materials science , nanotechnology , oxygen , organic chemistry , polymer , ion
We report the design and synthesis of europium‐doped gadolinium oxysulfide nanoscintillators Gd 2 O 2 S:Eu 3+ conjugated with two different photosensitizers (PSs): a zinc chlorin (ZnTPC) and a zinc phtalocyanine (ZnPc) by covalent bonding through a layer of N ‐(3‐trimethoxysilylpropyl)diethylenetriamine (TPDA). These conjugates were designed to be activated under X‐ray excitation to allow a photodynamic effect, although this desired outcome was not achieved in this study. The monodispersed nanoparticles of ∼70 nm diameter were pegylated to be stabilized in aqueous suspension. It was shown that the PSs conserved their photophysical properties once conjugated to the nanoscintillator and efficient singlet oxygen was obtained upon photo‐irradiation. However, no energy transfer was observed from the nanoscintillator to the photosensitizer neither under photo‐ nor X‐ray irradiation.