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Artocarpin‐enriched ( Artocarpus altilis ) Heartwood Extract Provides Protection Against UVB ‐induced Mechanical Damage in Dermal Fibroblasts
Author(s) -
Tiraravesit Narisara,
Humbert Philippe,
Robin Sophie,
Tissot Marion,
Viennet Céline,
Viyoch Jarupa
Publication year - 2017
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.12788
Subject(s) - fibroblast , chemistry , dermal fibroblast , contraction (grammar) , irradiation , biochemistry , in vitro , biology , endocrinology , physics , nuclear physics
This study aimed to evaluate the protective effect of artocarpin‐enriched ( Artocarpus altilis ) heartwood extract on the mechanical properties of UVB ‐irradiated fibroblasts. Human skin fibroblasts were pretreated with 50 μg/mL −1 extract and later irradiated with UVB (200 mJ/cm −2 ). They were then cultured within three‐dimensional of free‐floating and tense collagen lattices. The pretreatment of fibroblasts with the extract prior to UVB radiation showed cells protection against UVB ‐induced suppression of α ‐ SMA expression, fibroblast migration and contraction. These results reveal that the extract prevents mechanical damages induced by UVB irradiation in fibroblast‐embedded collagen lattices, and therefore, has a potential as a natural photo‐protectant.