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Phylogenetic and Functional Classification of the Photolyase/Cryptochrome Family
Author(s) -
Ozturk Nuri
Publication year - 2017
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.12676
Subject(s) - cryptochrome , photolyase , biology , phylogenetic tree , genetics , computational biology , protein family , function (biology) , dna repair , classification scheme , class (philosophy) , circadian clock , dna , gene , computer science , artificial intelligence , machine learning
The photolyase/cryptochrome ( PHR / CRY ) family is a large group of proteins with similar structure but very diverge functions such as DNA repair, circadian clock resetting and regulation of transcription. As a result of advances in the biochemistry of the CRY / PHR family and identification of new members, several adjustments have been made to the classification of this protein family. For example, a new class of PHR s, Class III , has been proposed. Furthermore, CRY s have been suggested to function as photosensory proteins in the primordial eye of sponge larvae. Additionally, a magnetosensory function has been attributed to certain CRY s. Recent advances in the field enabled us to propose a comprehensive classification scheme and nomenclatural system for this family. This review focuses on the computational and biochemical classifications of the PHR / CRY family. Several examples show that computational analysis can give a hinge about the function of newly discovered members before performing any biochemical study.