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Oxidative Modification in Human Hair: The Effect of the Levels of Cu ( II ) Ions, UV Exposure and Hair Pigmentation
Author(s) -
Grosvenor Anita J.,
Marsh Jennifer,
Thomas Ancy,
Ver James A.,
Harland Duane P.,
Clerens Stefan,
Dyer Jolon M.
Publication year - 2015
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.12537
Subject(s) - oxidative phosphorylation , chemistry , copper , oxidative stress , ion , biophysics , oxidative damage , pro oxidant , redox , biochemistry , biology , inorganic chemistry , organic chemistry
Abstract Protein oxidative degradation is implicated in a wide range of deleterious effects. For human hair, this oxidative damage can lead to significant observable changes in fiber physical and visual properties. A redox proteomic approach was applied to map molecular modification in human hair proteins and correlate this modification with the abundance of copper ( II ) ions, the levels of UV exposure and the general level of hair pigmentation. An increase in oxidative modification was observed with increasing copper ( II ) ion levels, regardless of the pigmentation level. Significantly, increased protein oxidative modification was also observed to occur in both lightly and darkly pigmented hair tresses even in the absence of irradiation, albeit at lower relative levels. Modification levels increased with increased copper ( II ) ion concentration. This new finding indicates that the level of copper ( II ) ions in human hair plays a key role in mediating protein oxidation, with or without exposure to UV light. Overall, these results strongly suggest that minimization of the level of copper ( II ) ions in human hair will mitigate and/or slow protein oxidative modification and therefore lower overall hair damage.