Premium
Photodynamic Diagnosis Using 5‐Aminolevulinic Acid in 41 Biopsies for Primary Central Nervous System Lymphoma
Author(s) -
Yamamoto Tetsuya,
Ishikawa Eiichi,
Miki Shunichiro,
Sakamoto Noriaki,
Zaboronok Alexander,
Matsuda Masahide,
Akutsu Hiroyoshi,
Nakai Kei,
Tsuruta Wataro,
Matsumura Akira
Publication year - 2015
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.12510
Subject(s) - primary central nervous system lymphoma , medicine , biopsy , pathological , pathology , stereotactic biopsy , lymphoma , gliosis , radiology
We evaluated the feasibility of 5‐aminolevulinic acid (5‐ ALA )‐mediated photodynamic diagnosis ( PDD ) in the biopsy for primary central nervous system lymphoma ( PCNSL ). 5‐ ALA (20 mg kg −1 ) was administered orally 4 hours preoperatively. Forty‐one biopsies obtained under PDD in 47 consecutive biopsies (46 patients) that were finally pathologically diagnosed as PCNSL were evaluated. Positive fluorescence was observed in 34 of those 41 biopsies (82.9%). An intraoperative pathological diagnosis ( IOD ) of suspected PCNSL was made in 21 of the biopsies with positive fluorescence (61.8%). However, the eight IOD s in the remaining 13 biopsies (23.5%) were not correct (atypical cell, 4; high‐grade glioma, 1; gliosis, 1; unremarkable, 2). In those 8 biopsies, PCNSL was confirmed by the final pathological diagnosis. There was no difference in the mean Mib‐1 labeling index between the biopsies with positive fluorescence (86.5%) and those without positive fluorescence (90.0%). IOD was not performed in 6 biopsies; however, 5 of those biopsies (83.3%) showed positive fluorescence and were finally pathologically diagnosed as PCNSL . Use of PDD in biopsies for patients with suspected PCNSL is a reliable way of obtaining specimens of adequate quality for the final pathological diagnosis and may lead to improved diagnostic yield in the biopsy of PCNSL .