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Influence of Trans Fat on Skin Damage in First‐Generation Rats Exposed to UV Radiation
Author(s) -
Barcelos Raquel Cristine S.,
Vey Luciana T.,
Segat Hecson Jesser,
Benvegnú Dalila M.,
Trevizol Fabíola,
Roversi Karine,
Roversi Katiane,
Dias Verônica T.,
Dolci Geisa S.,
Kuhn Fábio T.,
Piccolo Jaqueline,
CristinaVeit Juliana,
Emanuelli Tatiana,
Bürger Marilise E.
Publication year - 2015
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.12414
Subject(s) - antioxidant , offspring , oxidative stress , ultraviolet radiation , chemistry , biochemistry , food science , biology , pregnancy , genetics , radiochemistry
The influence of trans fatty acids ( TFA ) on lipid profile, oxidative damage and mitochondrial function in the skin of rats exposed to ultraviolet radiation ( UVR ) was assessed. The first‐generation offspring of female Wistar rats supplemented from pregnancy with either soybean oil (C‐ SO , rich in n –6 FA ; control group) or hydrogenated vegetable fat ( HVF , rich in TFA ) were continued with the same supplements until adulthood, when half of each group was exposed to UVR for 12 weeks. The HVF group showed higher TFA cutaneous incorporation, increased protein carbonyl ( PC ) levels, decreased functionality of mitochondrial enzymes and antioxidant defenses of the skin. After UVR , the HVF group showed increased skin thickness and reactive species ( RS ) generation, with decreased skin antioxidant defenses. RS generation was positively correlated with skin thickness, wrinkles and PC levels. Once incorporated to skin, TFA make it more susceptible to developing UVR ‐induced disorders.