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Micro RNA s and Photocarcinogenesis
Author(s) -
Syed Deeba N.,
Lall Rahul K.,
Mukhtar Hasan
Publication year - 2014
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.12346
Subject(s) - rna , biology , skin cancer , microrna , cancer research , basal cell carcinoma , gene , cancer , dna repair , human skin , dna damage , computational biology , dna , genetics , medicine , basal cell , pathology
As a new class of sequence‐specific regulators of gene expression, the micro RNA s (mi RNA ) form a regulatory network with growth factors and transcription factors participating in various biological processes. It is now being recognized that the various key processes involved in cancer induction are under the control of these small noncoding RNA s, which regulate ~30% of all human genes by targeting sequences in their 3′‐untranslated regions. Photocarcinogenesis is a complex interplay of signaling events in the UV exposed human skin including DNA damage and repair, apoptosis, cell survival, mutations and the immune system. In this review, we have scrutinized the role of mi RNA s in skin cancer biology focusing on the three most common types of skin cancer namely the basal cell carcinoma, squamous cell carcinoma and cutaneous malignant melanoma. An overview of these studies will be useful in gaining insights into the mechanisms of cancer development in the human skin. A better understanding of the functionality of mi RNA s will have enormous implications to risk assessment, and to target interventions against signaling events involved in photocarcinogenesis.