Premium
UVA Irradiation Induced Heme Oxygenase‐1: A Novel Phototherapy for Morphea
Author(s) -
Nisar Muhammad Farrukh,
Parsons Kimberly Suzanne George,
Bian Chun Xiang,
Zhong Julia Li
Publication year - 2014
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.12342
Subject(s) - morphea , localized scleroderma , heme oxygenase , heme , human skin , chemistry , irradiation , photoaging , dermatology , matrix metalloproteinase , cancer research , medicine , pathology , biology , biochemistry , fibrosis , enzyme , genetics , physics , lichen sclerosus , nuclear physics
Long wave UVA radiation (340–400 nm) causes detrimental as well as beneficial effects on human skin. Studies of human skin fibroblasts irradiated with UVA demonstrate increased expression of both antifibrotic heme oxygenase‐1 ( HO ‐1) and matrix metalloproteinase 1 ( MMP ‐1). The use of UVA ‐induced MMP ‐1 is well‐studied in treating skin fibrotic conditions such as localized scleroderma, now called morphea. However, the role that UVA ‐induced HO ‐1 plays in phototherapy of morphea has not been characterized. In the present manuscript, we have illustrated and reviewed the biological function of HO ‐1 and the use of UVA 1 wavebands (340–400 nm) for phototherapy; the potential use of HO ‐1 induction in UVA therapy of morphea is also discussed.