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Design of a Gd‐ DOTA ‐Phthalocyanine Conjugate Combining MRI Contrast Imaging and Photosensitization Properties as a Potential Molecular Theranostic
Author(s) -
Aydın Tekdaş Duygu,
Garifullin Ruslan,
Şentürk Berna,
Zorlu Yunus,
Gundogdu Umut,
Atalar Ergin,
Tekinay Ayse B.,
Cherosov Alexander A.,
Yerli Yusuf,
Dumoulin Fabienne,
Guler Mustafa O.,
Ahsen Vefa,
Gürek Ayşe Gül
Publication year - 2014
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.12332
Subject(s) - conjugate , dota , phthalocyanine , rational design , chemistry , moiety , biocompatibility , click chemistry , photodynamic therapy , mri contrast agent , combinatorial chemistry , nanotechnology , materials science , stereochemistry , chelation , gadolinium , organic chemistry , mathematical analysis , mathematics
The design and synthesis of a phthalocyanine – Gd‐ DOTA conjugate is presented to open the way to novel molecular theranostics, combining the properties of MRI contrast imaging with photodynamic therapy. The rational design of the conjugate integrates isomeric purity of the phthalocyanine core substitution, suitable biocompatibility with the use of polyoxo water‐solubilizing substituents, and a convergent synthetic strategy ended by the use of click chemistry to graft the Gd‐ DOTA moiety to the phthalocyanine. Photophysical and photochemical properties, contrast imaging experiments and preliminary in vitro investigations proved that such a combination is relevant and lead to a new type of potential theranostic agent.