Premium
The Injury and Cumulative Effects on Human Skin by UV Exposure from Artificial Fluorescence Emission
Author(s) -
Tian Yan,
Liu Wei,
Niu TianHui,
Dai CaiHong,
Li Xiaoxin,
Cui Caijuan,
Zhao Xinyan,
E Yaping,
Lu Hui
Publication year - 2014
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.12315
Subject(s) - photoaging , irradiation , transepidermal water loss , human skin , dermis , epidermis (zoology) , skin aging , fluorescence , chemistry , dose–response relationship , biophysics , medicine , dermatology , pathology , anatomy , biology , optics , physics , stratum corneum , nuclear physics , genetics
The injury and cumulative effects of UV emission from fluorescence lamp were studied. UV intensity from fluorescence lamp was measured, and human skin samples (hips, 10 volunteers) were exposed to low‐dose UV irradiation (three times per week for 13 consecutive weeks). Three groups were examined: control group without UV radiation; low‐dose group with a cumulative dose of 50 J cm −2 which was equivalent to irradiation of the face during indoor work for 1.5 years; and high‐dose group with 1000 J cm −2 cumulative dose equivalent to irradiation of the face during outdoor activities for 1 year. Specific indicators were measured before and after UVA irradiation. The findings showed that extending the low‐dose UVA exposure decreased the skin moisture content and increased the transepidermal water loss as well as induced skin color changes (decreased L * value, increased M index). Furthermore, irradiated skin showed an increased thickness of cuticle and epidermis, skin edema, light color and unclear staining collagen fibers in the dermis, and elastic fiber fragmentation. In addition, MMP ‐1, p53 and SIRT 1 expression was also increased. Long‐term exposure of low‐dose UVA radiation enhanced skin photoaging. The safety of the fluorescent lamp needs our attention.