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Gold Nanorod‐Assembled PEGylated Graphene‐Oxide Nanocomposites for Photothermal Cancer Therapy
Author(s) -
Dembereldorj Uuriintuya,
Choi Seon Young,
Ganbold ErdeneOchir,
Song Nam Woong,
Kim Doseok,
Choo Jaebum,
Lee So Yeong,
Kim Sehun,
Joo SangWoo
Publication year - 2013
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.12212
Subject(s) - photothermal therapy , graphene , nanocomposite , materials science , nanotechnology , nanorod , photothermal effect , peg ratio , transmission electron microscopy , finance , economics
Gold nanorod‐attached PEG ylated graphene‐oxide (Au NR ‐ PEG ‐ GO ) nanocomposites were tested for a photothermal platform both in vitro and in vivo . Cytotoxicity of AuNR was reduced after encapsulation with PEG ‐ GO along with the removal of cetyltrimethylammonium bromide ( CTAB ) from AuNR by HC l treatment. Cellular internalization of the CTAB ‐eliminated AuNR ‐ PEG ‐ GO nanocomposites was examined using dark‐field microscopy ( DFM ), confocal Raman microscopy and transmission electron microscopy ( TEM ). To determine the photothermal effect of the AuNR ‐ PEG ‐ GO nanocomposites, A431 epidermoid carcinoma cells were irradiated with Xe‐lamp light (60 W cm −2 ) for 5 min after treatment with the AuNR ‐ PEG ‐ GO nanocomposites for 24 h. Cell viability significantly decreased by ~40% when the AuNR ‐ PEG ‐ GO ‐encapsulated nanocomposites were irradiated with light as compared with the cells treated with only the AuNR ‐ PEG ‐ GO nanocomposites without any illumination. In vivo tumor experiments also indicated that HC l‐treated Au NR ‐ PEG ‐ GO nanocomposites might efficiently reduce tumor volumes via photothermal processes. Our graphene and AuNR nanocomposites will be useful for an effective photothermal therapy.