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Formation and Direct Repair of UV ‐induced Dimeric DNA Pyrimidine Lesions
Author(s) -
Kneuttinger Andrea Christa,
Kashiwazaki Gengo,
Prill Stefan,
Heil Korbinian,
Müller Markus,
Carell Thomas
Publication year - 2013
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.12197
Subject(s) - pyrimidine dimer , dna repair , dna , photolyase , chemistry , pyrimidine , dna damage , microbiology and biotechnology , biochemistry , biology
Direct repair of UV ‐induced DNA lesions represents an elegant method for many organisms to deal with these highly mutagenic and cytotoxic compounds. Although the participating proteins are structurally well investigated, the exact repair mechanism of the photolyase enzymes remains a vivid subject of current research. In this review, we summarize and highlight the recent contributions to this exciting field.