Premium
Coencapsulation of Butyl‐Methoxydibenzoylmethane and Octocrylene into Lipid Nanocarriers: UV Performance, Photostability and in vitro Release
Author(s) -
Niculae Gabriela,
Badea Nicoleta,
Meghea Aurelia,
Oprea Ovidiu,
Lacatusu Ioana
Publication year - 2013
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/php.12117
Subject(s) - nanocarriers , photoprotection , chemistry , solid lipid nanoparticle , zeta potential , uv filter , particle size , bioavailability , absorption (acoustics) , chromatography , nanoparticle , materials science , chemical engineering , nanotechnology , pharmacology , biochemistry , medicine , photosynthesis , physics , composite material , optics , engineering
Abstract The coencapsulation of two UV filters, butyl‐methoxydibenzoylmethane ( BMDBM ) and octocrylene ( OCT ), into lipid nanocarriers was explored to develop stable cosmetic formulations with broad‐spectrum photoprotection and slow release properties. Different types of nanocarriers in various concentrations of the two UV filters were tested to find the combination with the best absorption and release properties. Solid lipid nanoparticles ( SLN s) and nanostructured lipid carriers ( NLC s) have been the two types of lipid nanocarriers used. The NLC s were based on either medium chain triglycerides ( MCT ) or squalene ( Sq ). The following physicochemical properties of the nanocarriers have been evaluated: particle size, morphology, zeta potential (ZP), entrapment efficiency, loading capacity, and thermal behavior. The nanocarriers have been formulated into creams containing low amounts of UV filters (2.5% BMDBM and 1% OCT ). The best photoprotection results were obtained with the cream based on NLC s prepared with MCT , having a sun protection factor ( SPF ) of 17.2 and an erythemal UVA protection factor ( EUVA – PF ) of 50.8. The photostability of the encapsulated BMDBM filter was confirmed by subjecting the nanocarriers‐based creams to in vitro irradiation. The prolonged UV ‐protection efficacy was coupled with a slow in vitro release of the synthetic UV filters, which followed the Higuchi release model.