Premium
Insulin‐like receptor substrate gene chico regulates octopamine metabolism in D rosophila melanogaster
Author(s) -
Adonyeva Natalya V.,
Burdina Elena V.,
Rauschenbach Inga Yu.,
Menshanov Petr N.,
Gruntenko Nataly E.
Publication year - 2017
Publication title -
physiological entomology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.693
H-Index - 57
eISSN - 1365-3032
pISSN - 0307-6962
DOI - 10.1111/phen.12173
Subject(s) - octopamine (neurotransmitter) , biology , drosophila melanogaster , melanogaster , endocrinology , drosophilidae , medicine , biochemistry , receptor , gene , serotonin
Octopamine, one of the main insect biogenic amines, plays an important role in the control of fitness in D rosophila melanogaster M eigen. The present study examines the effects of a null mutation of the gene of the insulin‐like receptor substrate ( chico ), in the heterozygous state, on octopamine metabolism, heat stress resistance and fecundity of D . melanogaster . A rise in the activity of one of the key enzymes of octopamine synthesis, tyrosine decarboxylase, as well as that of an enzyme of its degradation, octopamine‐dependent N ‐acetyl transferase, is observed in chico 1/+ females. It is also found that the resistance to heat stress is decreased and fecundity is reduced dramatically in chico 1/+ flies. Such changes in these parameters in D . melanogaster females result from a rise in octopamine titre, which suggests that chico affects the octopamine level by regulating the activity of tyrosine decarboxylase.