Premium
Probable mechanism of sexual dimorphism in insulin control of Drosophila heat stress resistance
Author(s) -
Gruntenko Nataly E.,
Karpova Evgenia K.,
Burdina Elena V.,
Adonyeva Natalya V.,
Andreenkova Olga V.,
Alekseev Alexander A.,
Rauschenbach Inga Y.
Publication year - 2016
Publication title -
physiological entomology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.693
H-Index - 57
eISSN - 1365-3032
pISSN - 0307-6962
DOI - 10.1111/phen.12125
Subject(s) - biology , corpus allatum , juvenile hormone , endocrinology , medicine , drosophila melanogaster , sexual dimorphism , gene knockdown , insulin resistance , insulin , hormone , genetics , gene
Adult males of Drosophila species ( Drosophila melanogaster L. and Drosophila virilis ) show a lower tolerance to heat stress compared with females. The present study investigates the effects of RNA interference ( RNAi ) knockdown of the insulin‐like receptor in the corpus allatum of D. melanogaster males on dopamine metabolism and content, heat stress resistance and juvenile hormone metabolism. In male flies, the knockdown of insulin‐like receptor in the corpus allatum is shown to change metabolism of juvenile hormone but not dopamine. It is also shown that knockdown of the insulin‐like receptor in the corpus allatum results in a decrease of heat stress resistance in females but not males, and that juvenile hormone rescues this decrease. The results suggest that at least one of the ways in which insulin‐like growth factors affect heat stress resistance is by successive mediation through juvenile hormone and dopamine, which could lead to sexual dimorphism in the trait.