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Impact of nutritional status on prevalence of left ventricular hypertrophy in children undergoing liver transplant
Author(s) -
Nelson James A.,
Mortensen Melissa J.,
Horslen Simon,
Bhat Aarti H.
Publication year - 2021
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.14011
Subject(s) - medicine , cohort , percentile , cardiology , left ventricular hypertrophy , retrospective cohort study , ventricular hypertrophy , blood pressure , statistics , mathematics
Objective We sought to (1) determine the prevalence of cardiac changes in patients with ESLD awaiting OLT (2) determine relationship between nutritional indices and cardiac changes. Methods Retrospective review of transthoracic ECHO, clinical and nutritional information of pediatric patients evaluated for OLT. ECHO was analyzed for LVH, defined as LVMI > 95 g/m 2.7 and/or RWT > 0.42. These findings were correlated with age, ESLD etiology, growth and nutritional parameters as well as pre‐ and post‐OLT. Results Sixty‐five patients were included, all had normal left ventricular systolic function. Nine patients (14%) had LVMI > 95 g/m 2.7 , five patients (8%) had RWT > 0.42, none met both criteria. None had thickened interventricular septal wall. Fourteen patients (20%) had significant left ventricular dilation. Nutritional deprivation was modestly present—weight under third percentile in 22%, length under third percentile in 24%, and both weight and length under third percentile in 17%. There were 12 patients (17%) with MUAC below two standard deviations for age; of these one had an elevated LVMI and another had an RWT > 0.42. Conclusions In this contemporary cross‐sectional evaluation, a smaller proportion of patients with ESLD had LVH in contrast to prior studies. Despite a comparable disease burden, our cohort had better nutritional status. Though there was a trend between nutritional and LVH indices, this correlation may be better assessed prospectively in a larger cohort.