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Fludarabine‐based reduced‐intensity conditioning regimen for hematopoietic stem cell transplantation in pediatric patient with IL10 receptor deficiency
Author(s) -
Kheder Maged,
Behfar Maryam,
Farajifard Hamid,
Ali Tahani,
Hkima Abou Fakher Faihaa,
Hamidieh Amir Ali
Publication year - 2021
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.13819
Subject(s) - medicine , fludarabine , regimen , hematopoietic stem cell transplantation , immune dysregulation , stem cell , transplantation , conditioning regimen , oncology , immunology , immune system , chemotherapy , cyclophosphamide , biology , genetics
IL‐10R deficiency results in severe immune dysregulation. Herein, we describe the successful treatment of a girl aged 6.8 years with IL10R deficiency by using RIC prior to HSCT from a matched unrelated donor. The regimen was well tolerated, the engraftment was completely attained. On a follow‐up of 7 months, the patient remained in good medical conditions with full donor chimerism. All complications before HSCT were completely resolved and her growth was accelerated. RIC regimen might be adequate to induce permanent engraftment and avoid severe organ toxicity in IL‐10R deficiency patients.