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Brincidofovir for the treatment of human adenovirus infection in pediatric solid organ transplant recipients: A case series
Author(s) -
Londeree Jackson,
Winterberg Pamela D.,
Garro Rouba,
George Roshan P.,
Shin Stella,
Liverman Rochelle,
Serluco Anastacia,
Romero Rene,
Yildirim Inci
Publication year - 2020
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.13769
Subject(s) - medicine , immunosuppression , viremia , disease , incidence (geometry) , pediatrics , intensive care medicine , immunology , virus , physics , optics
HAdV viremia can cause significant morbidity among pediatric recipients of SOT with variability in incidence and severity of disease based on the type of allograft. Currently, there are no US FDA–approved treatments for HAdV infections, and historically, the mainstay of treatment has been decreasing immunosuppression, with antiviral therapies reserved for those with severe disease. We describe the treatment of four pediatric SOT recipients (two kidney, one combined kidney‐liver, and one liver) presenting with HAdV disease at our institution using brincidofovir. Our case series highlights the variability in presentation and the potential for severe disease in pediatric SOT recipients as we review disease presentation, disease course, complications, and treatment with brincidofovir.