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Successful treatment of post‐transplant CMV meningoencephalitis with third‐party CMV virus‐specific T cells: Lessons learned
Author(s) -
Alonso Laura,
Rudilla Francesc,
Gimeno Ramón,
Codinach Margarita,
Blanco Margarita,
Querol Sergio,
Diaz de Heredia Cristina
Publication year - 2019
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.13584
Subject(s) - medicine , virology , meningoencephalitis , cytomegalovirus , virus , foscarnet , herpesviridae , viral disease
Cytomegalovirus encephalitis is a challenging life‐threatening complication following hematopoietic stem cell transplantation for which medical treatment is usually ineffective or toxic. However, in recent years, adoptive T‐cell therapy has been reported to provide a significant chance of cure for patients with viral infections. Herein, two cases of pediatric patients successfully treated with third‐party donor‐derived virus‐specific T cells for CMV meningoencephalitis are reported.