Successful treatment of post‐transplant CMV meningoencephalitis with third‐party CMV virus‐specific T cells: Lessons learned | Zendy

Alonso Laura | Zendy; Rudilla Francesc | Zendy; Gimeno Ramón | Zendy; Codinach Margarita | Zendy; Blanco Margarita | Zendy; Querol Sergio | Zendy; Diaz de Heredia Cristina | Zendy

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Successful treatment of post‐transplant CMV meningoencephalitis with third‐party CMV virus‐specific T cells: Lessons learned

Author(s) -

Alonso Laura,

Rudilla Francesc,

Gimeno Ramón,

Codinach Margarita,

Blanco Margarita,

Querol Sergio,

Diaz de Heredia Cristina

Publication year - 2019

Publication title -

pediatric transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 69

eISSN - 1399-3046

pISSN - 1397-3142

DOI - 10.1111/petr.13584

Subject(s) - medicine , virology , meningoencephalitis , cytomegalovirus , virus , foscarnet , herpesviridae , viral disease

Cytomegalovirus encephalitis is a challenging life‐threatening complication following hematopoietic stem cell transplantation for which medical treatment is usually ineffective or toxic. However, in recent years, adoptive T‐cell therapy has been reported to provide a significant chance of cure for patients with viral infections. Herein, two cases of pediatric patients successfully treated with third‐party donor‐derived virus‐specific T cells for CMV meningoencephalitis are reported.

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