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Collaborative Brazilian pediatric renal transplant registry (CoBrazPed‐RTx): A report from 2004 to 2018
Author(s) -
de Souza Vandrea Carla,
Garcia Clotilde Druck,
Pestana Jose Medina,
Stopa Martins Suelen Bianca,
Porini Custódio Luciana de Fátima,
Bittencourt Viviane,
Rohde Roberta,
Simões Pires Izadora,
Camargo Maria Fernanda de,
Koch Nogueira Paulo,
Feltran Luciana de Santis,
Esmeraldo Ronaldo de Matos,
Souza Costa Rebeca Carvalho,
Schvartsman Benita,
Watanabe Andreia,
Cunha Mariana Faucz Munhoz da,
Santos Romilda,
Prates Liliane Cury,
Belangero Vera Maria Santoro,
Palma Lilian,
Takase Henrique Mochida,
de Andrade Luiz Gustavo Mondelli,
Benini Vanda,
Laranjo Martins Simone Paiva,
AbbudFilho Mario,
FernandesCharpiot Ida,
Ramalho Horacio,
Quaresma Mendonça Ana Carmen,
Vasconcelos Mariana Affonso,
Andrade Nunes Claudia,
Penido de Paula Mariana Guimaraes,
Moura Diniz Ferreira Leite Carolina,
Russo Enzo Ricardo,
Facincani Inalda,
Wagner Mario Bernardes
Publication year - 2019
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.13463
Subject(s) - medicine , renal transplant , intensive care medicine , transplantation , pediatrics
The Brazilian collaborative registry for pediatric renal transplantation began in 2004 as a multicenter initiative aimed at analyzing, reporting, and disseminating the results of pediatric renal transplantation in Brazil. Data from all pediatric renal transplants performed from January 2004 to May 2018 at the 13 participating centers were analyzed. A total of 2744 pediatric renal transplants were performed in the thirteen participating centers. The median age at transplantation was 12.2 years, with the majority being male recipients (56%). The main underlying diseases were CAKUT (40.5%) and glomerulopathy (28%). 1981 (72%) of the grafts were from deceased donors (DD). Graft survival at one year (censored by death) was 94% in the live donor group (LD) and 91% in the DD group (log‐rank test P < 0.01). The patient’s survival at one and 5 years was 97% and 95% for the LD group and 96% and 93% for the DD group (log‐rank test P = 0.02). The graft loss rate was 19% (n = 517), more frequently caused by vascular thrombosis (n = 102) and chronic graft nephropathy (n = 90). DD recipients had 1.6 (1.0‐2.2) times greater chance of death and 1.5 (1.2‐1.8) times greater chance of graft loss compared to LD recipients. The mortality rate was 5.4% (n = 148), mainly due to infection (n = 69) and cardiovascular disease (n = 28). The results of this collaborative pediatric renal transplant record are comparable to other international registries, although we still have a high infection rate as a cause of death.