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Success of chemotherapy and a liver transplant in a pediatric patient with hepatic angiosarcoma: A case report
Author(s) -
Pilbeam Kristy,
Eidenschink Ben,
Sulciner Megan,
Luquette Mark,
Neglia Joseph,
Chinnakotla Srinath
Publication year - 2019
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.13410
Subject(s) - medicine , angiosarcoma , ifosfamide , chemotherapy , liver transplantation , sarcoma , doxorubicin , surgery , docetaxel , hemangiosarcoma , radiology , transplantation , pathology , etoposide
Hepatic angiosarcoma is an extremely rare diagnosis in children, with fewer than 50 pediatric cases reported in the literature worldwide. This aggressive vascular sarcoma carries a very dismal prognosis and is known to be resistant to radiation, chemotherapy, and other vascular‐targeted agents. Complete surgical resection is felt to provide the best chance for long‐term survival. In patients with tumors not amenable to resection, a liver transplant can be considered. However, very few such transplants have been reported, given that they remain controversial due to high cancer recurrence and mortality post‐transplant. Herein, we report the unique case of a 2‐year‐old child with localized hepatic angiosarcoma not amendable to resection who successfully underwent a liver transplant and received chemotherapy with six cycles of doxorubicin, docetaxel, and ifosfamide.