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Successful treatment of pulmonary mucormycosis in two pediatric hematopoietic stem cell transplant patients
Author(s) -
Elgarten Caitlin W.,
Levy Ellen M.,
Mattei Peter,
Fisher Brian T.,
Olson Timothy S.,
Freedman Jason L.
Publication year - 2018
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.13270
Subject(s) - medicine , mucormycosis , immunosuppression , hematopoietic stem cell transplantation , intensive care medicine , antifungal , stem cell , multidisciplinary team , hematopoietic stem cell , transplantation , surgery , haematopoiesis , dermatology , nursing , biology , genetics
Pulmonary mucormycosis diagnosed immediately after hematopoietic stem cell transplantation frequently portends a poor prognosis. However, here we describe two cases in children that were treated successfully to highlight the efficacy of a multidisciplinary approach. Despite diagnosis in the immediate post‐transplant period and requirement for ongoing immunosuppression to prevent or treat GVHD, both are long‐term survivors due to early surgical debridement with transfusion support and prompt initiation of targeted antifungal therapy. In the absence of evidence‐based treatment guidelines, survival of pulmonary mucormycosis is achievable even in high‐risk patients with a multidisciplinary team to guide management.