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Clinical course of human herpesvirus 6 infection in pediatric living donor liver transplantation
Author(s) -
Yasui Toshihiro,
Suzuki Tatsuya,
Yoshikawa Tetsushi,
Yatsuya Hiroshi,
Kawamura Yoshiki,
Miura Hiroki,
Hara Fujio,
Watanabe Shunsuke,
Uga Naoko,
Naoe Atsuki
Publication year - 2018
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.13239
Subject(s) - medicine , biliary atresia , liver transplantation , gastroenterology , retrospective cohort study , transplantation , cohort , human herpesvirus 6 , multivariate analysis , immunology , viral disease , herpesviridae , virus
Differentiation between active and latent viral infection is critical for analysis of HHV ‐6‐associated disease. HHV ‐6 infection has been associated with several clinical manifestations; however, the precise role of HHV ‐6 in pediatric LDLT remains unclear. This retrospective cohort study included 33 pediatric patients who received LDLT . All of the recipients were monitored for HHV ‐6 infection using viral isolation and real‐time PCR . HHV ‐6 infection was observed in 14 of 33 (42.4%) recipients, and HHV ‐6B infection occurred within 2 weeks after LDLT in 10 of 14 (71.4%) recipients. HHV ‐6 was isolated from 10 of 33 (30.3%) recipients. Multivariate analysis showed that independent predictors of HHV ‐6B infection were age ( OR 0.975; 95% CI 0.943‐0.999; P = .041), PELD ( OR 1.091; P = .038), and biliary atresia ( OR 16.48; P = .035). The occurrence of unexplained fever was significantly higher in recipients with HHV ‐6B infection (11/14) compared with uninfected recipients (6/19) ( P = .013). Additionally, ALT levels at 8 and 9 weeks after transplantation were significantly higher in the recipients with HHV ‐6B infection. Younger age, high MELD / PELD score, and biliary atresia as an underlying disease were identified as risk factors for viral infection.