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Chronic neutrophilic leukemia, an extremely rare cause of neutrophilia in childhood: Cure with hematopoietic stem cell transplantation
Author(s) -
Uygun Vedat,
Daloğlu Hayriye,
Öztürkmen Seda,
Karasu Gülsün,
Avcı Zekai,
Yeşilipek Akif
Publication year - 2018
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.13199
Subject(s) - medicine , neutrophilia , leukocytosis , hematopoietic stem cell transplantation , leukopenia , transplantation , leukemia , pediatrics , stem cell , chemotherapy , biology , genetics
CNL is a rare myeloproliferative disorder frequently seen in older adults. A significant proportion of patients show progression to AML . Here, we report the case of a patient with FA who was monitored for leukopenia but who developed leukocytosis during the follow‐up and was diagnosed with CNL probably after an acquired CSF 3R mutation. Because the patient had FA , which could accelerate the progression to AML , an HSCT was performed, which resulted in cure. This patient (aged 12 years) is one of the youngest patients reported to develop CNL as well as the first FA patient with a diagnosis of CNL .