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Outcomes of single kidney transplantation from pediatric donors: A single‐center experience
Author(s) -
Jiang Yamei,
Song Turun,
Qiu Yang,
Liu Jinpeng,
Wang Zhiling,
Wang Xianding,
Huang Zhongli,
Fan Yu,
Wang Li,
Lin Tao
Publication year - 2018
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.13196
Subject(s) - medicine , single center , incidence (geometry) , retrospective cohort study , cohort , transplantation , significant difference , kidney transplantation , overall survival , surgery , gastroenterology , pediatrics , physics , optics
Kidneys from pDD s are increasingly used to narrow the huge gap between incremental demand and static supply. However, there is still controversy on the clinical outcome of SKT from pDD s. We conducted a retrospective cohort study of 452 adult recipients in our center between March 2012 and February 2017. Outcomes of 3 groups, transplants with organs from pDD s (n=50), aDD s (n=207), and LD s (n=195), were compared. The mean age and weight of pDD s were 8.98 years (range 8 months‐17 years) and 30.05 kg (range 8.2‐55 kg), respectively. There was no difference in 1‐year (96.0%, 98.1%, and 99.0%, respectively, P =.277) and 3‐year patient survival (96.0%, 98.1%, and 99.0%, respectively, P =.277) or in 1‐year (96.0%, 96.6%, and 98.5%, P =.307) and 3‐year (96.0%, 96.6% and 97.9%, P =.437) graft survival. SC r, eGFR , and allograft size were similar among the 3 groups at 6th month post‐transplant and thereafter. Incidence of DGF was higher in patients of the aDD group than those in the pDD group (22.7% vs 10.0%, P <.001), but there was no difference in AR and infection. SKT from pDD s to adult recipients is effective and safe with acceptable outcomes, and it will be a promising expansion to the donor pool.