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Ribavirin therapy of hepatitis E infection may cause hyporegenerative anemia in pediatric renal transplant patients
Author(s) -
Klämbt Verena,
Panning Marcus,
Seidl Maximilian,
Häffner Karsten,
Pohl Martin
Publication year - 2018
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.13195
Subject(s) - ribavirin , medicine , anemia , renal transplant , gastroenterology , renal function , hepatitis c , hepatitis c virus , transplantation , immunology , virus
HEV infection can lead to chronic hepatitis in immunosuppressed patients; extrahepatic manifestations are rarely seen. Here, we report a 13‐year‐old renal transplant patient with chronic hepatitis E and renal involvement. Ribavirin therapy led to temporary virus clearance and amelioration of kidney function. However, ribavirin therapy caused severe hyporegenerative anemia, which has so far only been reported in patients treated with a combination of ribavirin and interferon alpha.