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Changes in left ventricular strain parameters following pediatric heart transplantation
Author(s) -
Godown Justin,
Dodd Debra A.,
Stanley Michael,
Havens Corey,
Xu Meng,
Slaughter James C.,
Bearl David W.,
Soslow Jonathan H.
Publication year - 2018
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.13166
Subject(s) - medicine , strain (injury) , population , transplantation , cardiology , longitudinal study , heart transplantation , pathology , environmental health
STE is increasingly utilized to assess strain in a variety of pathologies. Strain measurements have demonstrated utility following HT x and may aid in the detection of rejection and CAV . Strain parameters have not been well defined in the pediatric HT x population. This study aimed to describe strain in pediatric HT x recipients compared to controls and assess changes over time. All pediatric HT x recipients with available echocardiograms (2004‐2015) without rejection or CAV were identified. Longitudinal and circumferential strain was measured at <1 month, 1 year, 3 years, and 5 years post‐transplant and compared to controls. A total of 218 echocardiograms were analyzed in 79 HT x recipients. At <1 month post‐transplant, there was a significant decrement in longitudinal strain ( GLS −14.6 vs −19.2, P < .001) with concurrent augmentation of circumferential strain ( GCS −27.3 vs −24.3, P = .005). By 1 year post‐ HT x, all strain parameters normalized and were not significantly different from the control population. In the absence of graft complications, strain parameters did not change up to 5 years post‐transplant. Abnormal longitudinal strain parameters are present in the early post‐ HT x period with a compensatory increase in circumferential strain. These changes normalize by 1 year post‐transplant and do not change over time in the absence of graft complications.