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Pediatric ABO ‐incompatible kidney transplantation: Evolving with the advancing apheresis technology: A single‐center experience
Author(s) -
Sethi Sidharth Kumar,
Bansal Shyam Bihari,
Wadhwani Nikita,
Tiwari Aseem,
Arora Dinesh,
Sharma Reetesh,
Nandwani Ashish,
Yadav Dinesh Kumar,
Mahapatra Amit Kumar,
Jain Manish,
Jha Pranaw,
Ghosh Prasun,
Bhan Anil,
Dhaliwal Maninder,
Raghunathan Veena,
Kher Vijay
Publication year - 2018
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.13138
Subject(s) - medicine , abo blood group system , intensive care medicine , swap (finance) , kidney transplantation , transplantation , apheresis , single center , desensitization (medicine) , population , abo incompatibility , pediatrics , immunology , surgery , platelet , receptor , environmental health , finance , economics
Abstract Recent literature has endorsed favorable outcomes following ABO i kidney transplantation in pediatric population. Nevertheless, reluctance to pursue an ABO i still remains pervasive. This could be ascribed to various legitimate reasons, namely less extensive pediatric ABO i data, technical difficulties encountered during PP, cost restraints, and concerns regarding higher rates of antibody‐mediated rejection, infectious complications, and post‐transplant lymphoproliferative disorder as compared to adults. However, given the similar excellent outcomes of both ABO i and ABO c kidney transplantation, clinicians should consider this option sooner if a compatible donor or swap is not available. Here, we describe the outcomes of three pediatric ABO i performed at our institute in India (from 2014 till now), wherein distinct apheresis modalities had been employed in each desensitization protocol, and our techniques evolved with advancing science in apheresis. This case series includes India's first published pediatric ABO ‐incompatible transplant (Case 2) and the youngest child to undergo ABO ‐incompatible renal transplant in SAARC nations (Case 3).