Premium
Long‐term outcomes of simultaneous heart and kidney transplantation in pediatric recipients
Author(s) -
Weng Patricia L.,
Alejos Juan Carlos,
Hal Nancy,
Zhang Qiuheng,
Reed Elaine F.,
Tsai Chambers Eileen
Publication year - 2017
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.13023
Subject(s) - medicine , transplantation , renal function , single center , demographics , population , kidney transplantation , pediatrics , panel reactive antibody , heart transplantation , surgery , demography , environmental health , sociology
Pediatric sHKT x has become an effective therapy for patients with combined cardiac and renal failure. Often, these patients develop human leukocyte antigen antibodies from their previous allografts and are therefore more difficult to re‐transplant. We describe the largest case series of a predominantly sensitized pediatric sHKT x with emphasis on medical management and patient outcomes. Demographics, clinical characteristics, antibody, and biopsy data were retrospectively collected from University of California, Los Angeles database and correlated with short‐ and long‐term patient and allograft outcomes of all sHKT x performed between 2002 and 2015. We identified seven pediatric patients who underwent sHKT x at our center. Mean age at time of sHKT x was 13.7 years and 85.7% were re‐graft patients. 57.1% were sensitized with cPRA >50% and another 57.1% had preformed donor‐specific antibody. Five‐year renal allograft survival and patient survival was 85.7% for both end‐points. The remaining six patients are all alive (mean follow‐up 78.5 months) with good kidney and heart function. sHKT x in a population with increased immunological risk can be associated with good long‐term outcomes and offers potential guidance to the pediatric transplant community where data are limited.