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Determinants of large drain losses early after pediatric liver transplantation
Author(s) -
Marseglia Antonio,
Ginammi Marco,
Bosisio Michela,
Stroppa Paola,
Colledan Michele,
D'Antiga Lorenzo
Publication year - 2017
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12932
Subject(s) - medicine , ascites , liver dysfunction , organ dysfunction , liver transplantation , surgery , hepatic dysfunction , transplantation , gastroenterology , sepsis
The goal of this study was to evaluate postoperative ascites to correlate it with graft dysfunction and other complications. We therefore reviewed the files of patients transplanted between 2009 and 2014 to correlate drain losses with indication, patient and organ size, PELD , graft type, GRWR , NRBW , NGWD , cold ischemia time, histologically proven graft dysfunction, and surgical complications. Of 120 LT s in 104 patients, 48 (40%) were complicated by graft dysfunction, 43 (36%) by surgical complications, and 25 (21%) by cellular rejection. Large drain losses correlated with younger age ( P =.05), graft dysfunction ( P <.01), surgical complications ( P <.01), chylous ascites ( P =.05); there was no association with PELD , GRWR , NRBW , or NGWD . Graft dysfunction was predicted by >20 mL/kg/d of ascites at age 0‐2 years ( AUROC 0.671), and >10 mL/kg/d above 2 years ( AUROC 0.710). The measurement of drain losses after pediatric LT could be used as a non‐invasive marker of graft dysfunction. Younger recipients tend to develop larger amounts of ascites, and its persistence is associated with early complications.