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Association of cytotoxic T‐lymphocyte antigen 4 +49A/G gene polymorphism with acute rejection risk in renal transplantation
Author(s) -
Yang ChunHua,
Chen XueXia,
Chen Li,
Zheng DongHua,
Liu QiongShan,
Xie WenFeng
Publication year - 2017
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12916
Subject(s) - medicine , transplantation , genotype , meta analysis , allele , human leukocyte antigen , kidney transplantation , immunology , cytotoxic t cell , gastroenterology , gene , antigen , genetics , biology , in vitro
The conclusions on the association between cytotoxic T‐lymphocyte antigen 4 (CTLA4) +49A/G gene polymorphism and acute rejection risk in renal transplantation are still debated. This meta‐analysis was performed to update the association between CTLA4 +49A/G and acute rejection risk in renal transplantation. The association investigations were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using meta‐analysis method. Fourteen reports were included into this meta‐analysis for the association of CTLA4 A/G gene polymorphism and acute rejection risk in renal transplantation, consisting of 962 acute rejection patients and 2084 non‐acute rejection controls. The association between CTLA4 G allele/GG genotype and acute rejection risk in renal transplantation was found in this meta‐analysis (G allele: OR=1.21, 95% CI: 1.03‐1.44, P =.02; GG genotype: OR=1.37, 95% CI: 1.10‐1.69, P =.004). However, the AA genotype was not associated with acute rejection risk in renal transplantation. In conclusion, CTLA4 G allele/GG genotype is associated with the acute rejection risk in renal transplantation.